Oxygenated heterocyclic compounds

C - Chemistry – Metallurgy – 07 – D

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C07D 323/04 (2006.01) A61K 31/335 (2006.01) A61K 31/665 (2006.01) C07D 317/06 (2006.01) C07D 493/10 (2006.01) C07F 9/655 (2006.01)

Patent

CA 2104551

ABSTRACT Compound having antiparasitic properties are 1,2,4-trioxanes of the formula: Image (VII) in which: R1 and R2 together with the adjacent carbon atom form a cycloalkyl group which may be interrupted by an oxygen atom; R3 is a hydrogen atom or a hydroxyl group or etherified or esterified hydroxyl group having the exo or the endo configuration, which, when an etherified, esterified or aminated group, may be further functionalized with a phosphate, phosphonate, carbamate or carboxylate group; R4 is an aromatic substituent, optionally substituted with a halogen atom, an alkyl group, a trifluoromethyl group, an alkoxy-alkoxy group or an alkylamino group; and the dotted lines between positions 5 and 6 and positions 6 and 7 indicate that there is present a 5,6- or 6,7- double bond.

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