C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/18 (2006.01) A61K 31/70 (2006.01) A61K 38/18 (2006.01) A61K 48/00 (2006.01) C07K 14/475 (2006.01) C07K 14/495 (2006.01) C07K 16/22 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2248318
The present invention discloses Growth Factor HTTER36 polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating cellular growth and differentiation, bone formation and wound healing. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia and to prevent the formation of extracellular matrix molecules in the liver and lung. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.
La présente invention concerne des polypeptides de la famille des facteurs de croissance HTTER36 et des polynucléotides codant pour lesdits polypeptides. L'invention concerne aussi un procédé de production de tels polypeptides par des techniques de recombinaison ainsi que les utilisations thérapeutiques de ces polypeptides, qui comprennent la stimulation de la croissance et de la différentiation cellulaire, la formation osseuse et la cicatrisation. L'invention concerne en outre les antagonistes de tels polypeptides et leur utilisation thérapeutique contre la néoplasie et pour la prévention de la formation de molécules matricielles extracellulaires du foie et des poumons. L'invention concerne enfin des méthodes de diagnostic pour la détection des niveaux modifiés du polypeptide objet de la présente invention et des mutations dans les séquences d'acide nucléique codant pour les polypeptides de la présente invention.
Li Haodong
Soppet Daniel R.
Human Genome Sciences Inc.
Mbm Intellectual Property Law Llp
LandOfFree
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