Stabilized vitamin c formulations

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/375 (2006.01) A61K 8/67 (2006.01) A61K 47/10 (2006.01)

Patent

CA 2376303

The invention features a method of stabilizing free 1-ascorbic acid from oxidation by dispersing the free 1-ascorbic acid in a mixed glycol carrier and a solution containing the ascorbic acid inthe mixed glycol solution. The mixed glycol carrier contains a mixture of at least propylene glycol and butylene glycol, but may contain other glycols such as polyethylene glycol, and stabilizing and solubility assisting agents as well.

L'invention se rapporte à un procédé de stabilisation de l'acide L-ascorbique libre vis à vis de l'oxydation, qui consiste à disperser cet acide L-ascorbique libre dans un excipent à base d'un mélange de glycols. L'invention se rapporte également à une solution contenant l'acide ascorbique dans l'excipient à base du mélange de glycols. Ledit excipient à base d'un mélange de glycols contient un mélange composé au minimum de propylène glycol et de butylène glycol, mais il peut également contenir d'autre glycols tels que le polyéthylène glycol, ainsi que des agents de stabilisation et des agents facilitant la solubilisation.

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