Dermatitis treating agent

Details Dermatitis treating agent Dermatitis treating agent

A - Human Necessities

61

K

A61K 31/4709 (2006.01) A61K 31/4725 (2006.01) A61K 31/502 (2006.01) A61K 31/5377 (2006.01) A61P 17/00 (2006.01) A61P 17/06 (2006.01) A61P 17/08 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2624847

The present invention is to provide a topical dermatitis treating agent which comprises a pyridine compound represented by the following formula [I]: (see formula I) wherein R1 and R2 each represent a lower alkoxy group, =X- represents a group represented by the formula: (see formula II) or a group represented by the formula: =N-, Ring A represents a saturated or unsaturated bicyclic nitrogen-containing heterocyclic group having 1 to 4 substituents selected from hydroxyl group, oxo group, a lower alkoxy group, a di-lower alkylaminophenyl group, a pyperidino-lower alkoxy group, a morpholino-lower alkoxy group, a cyclo-lower alkylamino-lower alkylamino group, pyridyl group and morpholino group, and ()--- represents a single bond or a double bond, or a pharmaceutically acceptable salt thereof as an active ingredient.

La présente invention concerne un remède contre les dermatoses destiné à un usage externe, contenant comme ingrédient actif des composés représentés par la formule générale [I] ou des sels de ceux-ci acceptables sur le plan pharmaceutique. La formule [I], dans laquelle R1 et R2 sont chacun un alkoxy inférieur ; =X- est le groupe représenté par la formule suivante ou le groupe représenté par la formule : =N-; A est un groupe hétérobicyclique contenant de l~azote saturé ou non saturé comprenant un à quatre substituants sélectionnés parmi l'hydroxyle, l'oxo, l'alkoxy inférieur, le dialkylaminophényle inférieur, le pipéridinoalkoxy inférieur, le morpholinoalkoxy inférieur, le cycloalkylamino inférieur alkylamino inférieur, le pyridile et le morpholino ; et le symbole représente un lien simple ou double.

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