Three-dimensional nanocomposite materials consisting of a...

C - Chemistry – Metallurgy – 08 – L

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C08L 5/00 (2006.01) C08B 37/00 (2006.01)

Patent

CA 2731395

In the present invention nanocomposite materials in form of three-dimensional structure formed by a polymeric matrix consisting of a polysaccharidic composition of neutral or anionic polysaccharides and a branched cationic polysaccharides, in which metallic nanoparticles are uniformly dispersed and stabilized, are described. Using appropriate techniques of gelification or by means of an appropriate dehydration, the nanocomposite materials are three-dimensional matrices having different shapes in hydrated form as hydrogels, or in non-hydrated form. These nanocomposite materials have a broad-spectrum of strong bactericidal activity, but do not show any cytotoxicity. The particular antibacterial properties associated with metallic particle nano-scale and the presence of biological signals on the polymeric chains along with the lack of cytotoxicity may be exploited in developing new-generation biomaterials provided with antimicrobial properties and for many other applications in biomedical, pharmaceutical and food field.

La présente invention concerne des matériaux nanocomposites ayant une structure tridimensionnelle formée par une matrice polymère consistant en une composition polysaccharide de polysaccharides neutres ou anioniques et de polysaccharides cationiques ramifiés, dans lesquels les nanoparticules métalliques sont uniformément dispersées et stabilisées. En utilisant des techniques appropriées de gélification ou au moyen d'une déshydratation appropriée, les matériaux nanocomposites sont des matrices tridimensionnelles ayant des formes différentes sous une forme hydratée comme des hydrogels, ou sous une forme non hydratée. Ces matériaux nanocomposites ont un large spectre d'activité bactéricide forte, mais ne présentent aucune cytotoxicité. Les propriétés antibactériennes particulières associées à l'échelle nanométrique des particules métalliques et à la présence de signaux biologiques sur les chaînes polymères ainsi que l'absence de cytotoxicité peuvent être exploitées dans le développement de biomatériaux de nouvelle génération pourvus de propriétés antimicrobiennes et pour de nombreuses autres applications dans les domaines biomédicaux, pharmaceutiques et alimentaires.

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