Near ultraviolet-wavelength photonic-crystal biosensor with...

G - Physics – 01 – N

Patent

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G01N 21/47 (2006.01) B01L 3/00 (2006.01) G01N 21/25 (2006.01) G01N 33/551 (2006.01) G01N 33/552 (2006.01) G02B 5/18 (2006.01)

Patent

CA 2656162

Biosensors are disclosed based on one- or two-dimensional photonic-crystal reflectance filters operating at near-ultraviolet wavelengths. Rigorous Coupled- Wave Analysis simulations predict a more tightly confined resonant electric field at the surface of this biosensor as compared to previously fabricated near-infrared photonic-crystal biosensors. This change in the resonant electric field provides an improvement of over 4.5 times in the surface-sensitivity to bulk-sensitivity ratio, and therefore enables enhanced detection resolution for biomolecules adsorbed on the biosensor surface. These new biosensors can be fabricated in mass by replica molding. They are especially well suited for applications requiring the detection of small molecules or ultra-low analyte concentrations.

La présente invention concerne des biocapteurs, basés sur des filtres de réflectance de cristal photonique à une ou deux dimensions fonctionnant à des longueurs d'onde proches des ultraviolets. Des simulations rigoureuses d'analyse d'onde couplée prédisent un champ électrique résonant fortement confiné sur la surface de ce biocapteur par rapport aux biocapteurs à cristal photonique proche de l'infrarouge précédemment fabriqués. Ce changement du champ électrique résonant apporte une amélioration de plus de 4,5 fois dans le rapport entre sensibilité de surface et sensibilité de gros et permet donc une résolution de détection améliorée pour des biomolécules adsorbées sur la surface du biocapteur. Ces nouveaux biocapteurs peuvent être fabriqués en masse par un moulage de réplique. Ils sont particulièrement adaptés aux applications nécessitant la détection de petites molécules ou des concentrations d'analyte ultra-faibles.

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