Treatment and prevention of ischemic injury using activated...

Details Treatment and prevention of ischemic injury using activated... Treatment and prevention of ischemic injury using activated...

A - Human Necessities

61

K

A61K 38/48 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2662650

Methods and compositions are provided for treating or preventing ischemic injury in a tissue flap in order to reduce the incidence of flap necrosis. Some compositions comprise one or more of an activated protein C (APC), a functional fragment of an APC, an APC mimetic compound, and a derivative of APC. Some methods comprise administering to a subject a therapeutically effective amount of an agent comprising one or more of an activated protein C (APC), a functional fragment of an APC, an APC mimetic compound, and a derivative of APC.

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