Cytochrome p450rai-2 and related proteins

Details Cytochrome p450rai-2 and related proteins Cytochrome p450rai-2 and related proteins

C - Chemistry, Metallurgy

12

N

C12N 15/53 (2006.01) A61K 31/7088 (2006.01) A61K 38/44 (2006.01) A61K 48/00 (2006.01) A61P 17/00 (2006.01) A61P 17/06 (2006.01) A61P 17/10 (2006.01) A61P 35/00 (2006.01) C07K 16/40 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/02 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) C12N 15/861 (2006.01) C12P 19/34 (2006.01) C12P 21/02 (2006.01) C12Q 1/02 (2006.01) C12Q 1/26 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) G01N 33/573 (2006.01) A61K 38/0

Patent

CA 2396511

The present invention provides a novel all-trans-RA inducible all-trans-RA metabolizing cytochrome P450, P450RAI-2, that is predominantly expressed in the brain, cerebellum in particular. Human P450RAI-2 show 42 % amino acid identity to human P450RAI-1 and when transfected into COS-1 cells causes the rapid conversion of all-trans-RA into more polar metabolites including the inactive products 4-oxo-RA, 4-OH-RA and 18-OH-RA. P450RAI-2, as with P450RAI- 1, is also inducible in certain cultured cell lines exposed to all-trans-RA. Methods for and uses of the new polynucleotide, polypeptide, fragments thereof and inhibitors thereof, include the treatment of dermatological disorders and cancer.

La présente invention concerne un acide tout-trans rétinoïque inductible d'acide tout-trans rétinoïque métabolisant le cytochrome P450, P450RAI-2, qui est exprimé de façon prédominante dans le cerveau, en particulier dans le cervelet. La protéine P450RAI-2 humaine est identique à 42 % à la protéine P450RAI-1 humaine et lorsqu'elle est transfectée dans des cellules COS-1 elle entraîne une conversion rapide de tous les acides tout-trans rétinoïques dans plus de métabolites polaires comprenant les produits inactifs 4-oxo-RA, 4-OH-RA et 18-OH-RA. La protéine P450RAI-2, comme la protéine P450RAI-1, est aussi inductible dans certaines lignées de cellules de culture exposées à l'acide tout-trans rétinoïque. Cette invention concerne aussi des techniques d'utilisation de ce polynucléotide, ce polypeptide, des fragments de ceux-ci et des inhibiteurs de ceux-ci, notamment le traitement de troubles dermatologiques et du cancer.

Affiliated with

Also associated with

Rating

Cytochrome p450rai-2 and related proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cytochrome p450rai-2 and related proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cytochrome p450rai-2 and related proteins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1528120