Heterocyclic compounds as calcium channel blockers

Details Heterocyclic compounds as calcium channel blockers Heterocyclic compounds as calcium channel blockers

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/496 (2006.01) A61P 3/14 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2653497

Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted N-type calcium channel activity are disclosed. Specifically, a series of heterocyclic compounds are disclosed of the general formula (1) where X1 and X2 are linkers and W is an optionally substituted imidazolyl, oxazolyl, thiazolyl, benzimidazolyl, benzoxazolyl, or benzothiazolyl.

L'invention concerne des procédés et des composés efficaces pour traiter des troubles caractérisés par une activité indésirable des canaux calciques, en particulier des canaux calciques de type N. L'invention concerne plus spécifiquement une série de composés hétérocycliques de formule générale (1), dans laquelle X1 et X2 sont des groupes de liaison et W représente un radical imidazolyle, oxazolyle, thiazolyle, benzimidazolyle, benzoxazolyle ou benzothiazolyle éventuellement substitué.

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