C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/00 (2006.01) A61K 39/395 (2006.01) C12P 21/00 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2707304
The invention provides a polypeptide containing at least one IgG Fc region, wherein said at least one IgG Fc region is glycosylated with at least one galactose moiety connected to a respective terminal sialic acid moiety by a .alpha. 2,6 linkage, and wherein said polypeptide having a higher anti-inflammatory activity as compared to an unpurified antibody.
L'invention a pour objet un polypeptide contenant au moins une région IgG Fc, ladite au moins une région IgG Fc étant glycosylée avec au moins un fragment de galactose connecté à un fragment d'acide sialique terminal par une liaison a 2,6, et ledit polypeptide ayant une activité anti-inflammatoire supérieure à celle d'un anticorps non purifié.
Kaneko Yoshikatsu
Nimmerjahn Falk
Ravetch Jeffrey
Osler Hoskin & Harcourt Llp
The Rockefeller University
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