Use of vectors expressing intracellular polynucleotide...

Details Use of vectors expressing intracellular polynucleotide... Use of vectors expressing intracellular polynucleotide...

A - Human Necessities

61

K

A61K 39/39 (2006.01) A61K 39/00 (2006.01) A61P 37/02 (2006.01) A61P 37/04 (2006.01)

Patent

CA 2758327

An object of the invention is to provide a vaccine adjuvant that is comprised of a vector capable of expressing a polynucleotide binding protein in excess of levels already present in cells. Expression of the polynucleotide binding protein initiates intracellular pathways that lead to expression of type 1 interferons. In concert with expression of type 1 interferons, other cytokines are expressed, and the immune response to vaccine antigens given with the adjuvant is enhanced.

Un objet de l'invention est de fournir un adjuvant de vaccin qui renferme un vecteur capable d'exprimer une protéine de liaison à un polynucléotide en excès par rapport aux niveaux déjà présents dans les cellules. L'expression de la protéine de liaison à un polynucléotide initie des voies intracellulaires qui conduisent à une expression d'interférons de type (I). Conjointement avec l'expression d'interférons de type (I), d'autres cytokines sont exprimées, et la réponse immunitaire à des antigènes vaccinaux administrés avec l'adjuvant est augmentée.

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