Shaped implant material with antibiotic salts

A - Human Necessities – 61 – L

Patent

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Details

A61L 27/58 (2006.01) A61K 9/00 (2006.01) A61K 31/7036 (2006.01) A61L 27/54 (2006.01) A61P 31/00 (2006.01)

Patent

CA 2570758

The present invention is based on the problem to provide an implant material that is suitable for use as a locally applicable antibiotic reservoir for the treatment of osteomyelitis. This problem has been solved by a medical device for implantation which comprises form bodies arranged on a biodegradable filament and separated by a distance of 1 mm to 25 mm, wherein the form bodies consist of at least one member selected from the group of antibiotic salts consisting of gentamicin myristate, gentamicin palmitate, gentamicin stearate, tobramycin myristate, tobramycin palmitate, tobramycin stearate, amikacin myristate, amikacin palmitate, amikacin stearate, vancomycin palmitate, vancomycin stearate, ramoplanin palmitate, ramoplanin stearate, levofloxacin palmitate, levofloxacin stearate, ofloxacin palmitate, ofloxacin stearate, oxifloxacin palmitate, moxifloxacin stearate, clindamycin palmitate, and clindamycin stearate.

La présente invention vise à résoudre le problème suivant : mettre au point un implant à utiliser comme réservoir d'antibiotiques que l'on applique localement pour traiter l'ostéomyélite. Ce problème a été résolu par le recours à un dispositif médical à implanter, qui comprend des structures disposées sur un filament biodégradable et séparées par une distance de 1 mm à 25 mm. Les structures contiennent au moins un des éléments choisi parmi les sels d'antibiotique suivants : myristate de gentamicine, palmitate de gentamicine , stéarate de gentamicine, myristate de tobramycine, palmitate de tobramycine, stéarate de tobramycine, myristate d'amikacine, palmitate d'amikacine, stéarate d'amikacine, palmitate de vancomycine, stéarate de vancomycine, palmitate de ramoplanine, stéarate de ramoplanine, palmitate de lévofloxacine, stéarate de lévofloxacine, palmitate d'ofloxacine, stéarate d'ofloxacine, palmitate d'oxifloxacine, stéarate de moxifloxacine, palmitate de clindamycine et stéarate de clindamycine.

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