Gene expression profiles that identify genetically elite...

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01)

Patent

CA 2531197

Genetically elite ungulate mammals are identified on the basis of gene expression profiles from biological samples such as liver and blood. Methods and compositions are presented to select genetically elite animals with a desired phenotype such as high milk production for breeding to improve production levels. A method to select an animal with a specific phenotype, e.g. milk production and health traits, includes creating a Gene Expression Index for a specific phenotype and using the index to identify candidate animals for breeding by comparing the index to gene expression profiles of the animals.

On peut identifier les mammifères ongulés constituant génétiquement des élites en identifiant leurs profils d'expression de gènes à partir d'échantillons biologiques par exemple du foie ou du sang. A cet effet l'invention porte: sur des méthodes et des compositions de sélection des animaux d'élite présentant un phénotype recherché tel qu'une production élevée de lait améliorant les niveaux de reproduction; et sur une méthode de sélection d'un animal de phénotype donné, par exemple la production de lait et le niveau sanitaire, consistant à créer un index d'expression des gènes pour le phénotype donné, et à utiliser l'index pour identifier les animaux candidats à la reproduction, en comparant l'index aux profils d'expression de gènes des animaux.

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