Prostate-specific kallikrein

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 9/64 (2006.01) C12N 15/57 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2270291

The present invention provides a human prostate-specific kallikrein (HPSK) and polynucleotides which identify and encode HPSK. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HPSK and a method for producing HPSK. The invention also provides for agonists, antibodies, or antagonists specifically binding HPSK, and their use, in the prevention and treatment of diseases associated with expression of HPSK. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HPSK for the treatment of diseases associated with the expression of HPSK. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HPSK.

La présente invention porte sur une kallikréine humaine spécifique de la prostate et sur des polynucléotides identifiant et codant cette kallikréine. L'invention porte également sur des vecteurs d'expression obtenus par génie génétique et sur des cellules hôtes comprenant les séquences d'acide nucléique codant la nouvelle kallikréine, ainsi que sur des procédés de production de cette kallikréine. L'invention porte encore sur des agonistes, des anticorps ou des antagonistes liant spécifiquement la nouvelle kallikréine, et sur leur utilisation dans la prévention et le traitement de maladies associées à l'expression de cette nouvelle kallikréine. L'invention porte en outre sur des méthodes diagnostiques utilisant le polynucléotide ou ses fragments ou son complément, ainsi que les anticorps liant spécifiquement la nouvelle kallikréine.

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