Method of activating soluble carbohydrate using novel...

Details Method of activating soluble carbohydrate using novel... Method of activating soluble carbohydrate using novel...

A - Human Necessities

61

K

A61K 39/385 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2171942

A process is described for producing an immunogenic construct comprising activating at least one first carbohydrate-containing moiety with a novel cyanylating reagent and covalently joining said activated first moiety to a second moiety. Immunogenic constructs may be prepared by this process using either direct conjugation of first and second moieties or using indirect conjugation with a bifunctional reagent.

Procédé de production d'une structure immunogène selon lequel on active au moins une première fraction contenant un glucide avec un nouveau réactif cyanylant puis on lie par covalence cette première fraction activée à une deuxième fraction. On peut préparer, à l'aide de ce procédé, des structures immunogènes soit par conjugaison directe de première et deuxième fractions, soit par conjugaison indirecte avec un réactif bifonctionnel.

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