C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/078 (2006.01) A61K 38/05 (2006.01) A61K 38/06 (2006.01) C07K 5/065 (2006.01) C07K 5/08 (2006.01) C07K 5/087 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2052013
Thrombin inhibitors represented by the formula (see formula I) as provided wherein A(C=O)- is, inter alia, phenylglycyl, cyclohexylglycyl, cyclohexenylglycyl, thienylglycyl or naphthylglycyl, wherein the .alpha.-amino group is preferably substituted by alkyl e.g. methyl or an alkoxycarbonyl, cycloalkoxycarbonyl or arylkoxycarbonyl group e.g. t-butyloxycarbonyl. A(C=O)- also represents an .alpha.-substituted acetyl group such as .alpha.-methoxyphenylacetyl; or a bicyclic group such as a tetrahydroisoquinolin-1-oyl group; or a 1-amino or (substituted amino) cycloalkylcarbonyl group such as 1-aminocyclohexylcarbonyl. Also provided are a method for inhibiting the formation of blood clots in man and animals by administering a thrombin inhibitor of the above formula and pharmaceutical formulations useful in the method.
Gesellchen Paul D.
Shuman Robert T.
Eli Lilly And Company
Gowling Lafleur Henderson Llp
LandOfFree
Tripeptide antithrombotic agents does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Tripeptide antithrombotic agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tripeptide antithrombotic agents will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1531441