A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/502 (2006.01) A61K 31/34 (2006.01) A61K 47/10 (2006.01) A61K 47/12 (2006.01) A61K 47/18 (2006.01) A61K 47/38 (2006.01) A61K 9/22 (2006.01)
Patent
CA 2652135
The invention provides solid dosage formulations, methods of making and using the formulations comprising at least one hydralazine compound or a pharmaceutically acceptable salt thereof, and at least one excipient or carrier, wherein the formulations have less than about 0.001 % to about 0.1 % of a hydrazone compound based on the total weight of the formulation. The invention also provides solid dosage formulations, methods of making and using the formulations comprising at least one hydralazine compound or a pharmaceutically acceptable salt thereof, and at least one nitric oxide donor compound or a pharmaceutically acceptable salt thereof and at least one excipient or carrier, wherein the formulations have less than about 0.001 % to about 0.1% of a hydrazone compound based on the total weight of the formulation.
Cette invention concerne des formulations en doses solides et des procédés de préparation et d'utilisation de ces formulations, lesquelles comprennent au moins un composé d'hydralazine ou un sel pharmaceutiquement acceptable de celui-ci, et au moins un excipient ou vecteur, lesquelles formulations contiennent moins de 0,001 à 0,1% environ d'un composé d'hydrazone sur la base du poids total de la formulation. Cette invention concerne également des formulations en doses solides et des procédés de préparation et d'utilisation de ces formulations, lesquelles comprennent un composé d'hydralazine ou un sel pharmaceutiquement acceptable de celui-ci, au moins un composé donneur d'oxyde nitrique ou un sel pharmaceutiquement acceptable de celui-ci et au moins un excipient ou vecteur, lesquelles formulations contiennent moins de 0,001 à 0,1% environ d'un composé d'hydrazone sur la base du poids total de la formulation.
Bennett Jones Llp
Nitromed Inc.
LandOfFree
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