Pyrimidine derivatives for the treatment of abnormal cell...

Details Pyrimidine derivatives for the treatment of abnormal cell... Pyrimidine derivatives for the treatment of abnormal cell...

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07D 403/14 (2006.01)

Patent

CA 2566477

The present invention relates to a compound of the formula (1) wherein A and Ar are as defined herein. Such novel pyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

L'invention concerne un composé représenté par la formule (I), dans laquelle A et Ar sont définis. Ces nouveaux dérivés de pyrimidine sont utiles dans le traitement de la croissance cellulaire anormale, notamment le cancer, chez des mammifères. Cette invention concerne également un procédé d'utilisation de ces composés dans le traitement de la croissance cellulaire anormale chez des mammifères, notamment des humains, ainsi que des compositions pharmaceutiques contenant ces composés.

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