Mutants of the rb and p53 genes and uses thereof

Details Mutants of the rb and p53 genes and uses thereof Mutants of the rb and p53 genes and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 14/82 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2208706

The present invention provides mutants of the Rb and p53 genes and methods utilizing these mutants therapeutically. Along with mutated Rb genes and p53 genes, the present invention provides plasmids containing a mutated Rb gene or a p53 gene. In addition, the present invention provides cells transfected with the plasmids of the present invention. Moreover, the present invention provides for methods of treating a variety of pathophysiological cell proliferative diseases.

L'invention porte sur des mutants des gènes Rb et p53 et leur procédé d'utilisation à des fins thérapeutiques ainsi que sur des plasmides contenant lesdits gènes mutés. Elle porte en outre sur des cellules transfectées à l'aide desdits plasmides et sur des procédés de traitement de différents états pathologiques liés à la prolifération de cellules.

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