Method of making small liposomes

Details Method of making small liposomes Method of making small liposomes

A - Human Necessities

61

K

A61K 9/127 (2006.01) C07K 14/775 (2006.01)

Patent

CA 2747182

Liposomes of constrained particle size are prepared by substantially continuously mixing substantially continuously flowing streams of water, and of an organic solvent contain lipid(s) capable of forming liposomes, and cooling the mixture so liposomes form, the ratio of the flow rate of the stream of water to the flow rate of the stream of organic solvent, and the rate of cooling of said mixture, being controlled so as to obtain a preparation of liposomes such that at least about 90% of the liposomes are of a particle size less than about 200 nm.

La présente invention concerne des liposomes ayant une taille de particules restreinte qui sont préparés par mélange sensiblement continu de courants d'eau à écoulement sensiblement continu, et d'un solvant organique, qui contiennent un (des) lipide(s) capable(s) de former des liposomes, et par refroidissement du mélange pour que des liposomes se forment, le rapport de la vitesse d'écoulement du courant d'eau sur la vitesse d'écoulement du courant de solvant organique, et la vitesse de refroidissement dudit mélange, étant maîtrisés de manière à obtenir une préparation de liposomes telle qu'au moins environ 90 % des liposomes ont une taille de particules inférieure à environ 200 nm.

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