Benz/e/indene derivatives

Details Benz/e/indene derivatives Benz/e/indene derivatives

C - Chemistry, Metallurgy

07

C

C07C 251/58 (2006.01) A61K 31/15 (2006.01) A61K 31/335 (2006.01) A61K 31/395 (2006.01) C07C 271/60 (2006.01) C07D 209/48 (2006.01) C07D 213/74 (2006.01) C07D 231/12 (2006.01) C07D 233/61 (2006.01) C07D 239/34 (2006.01) C07D 295/088 (2006.01) C07D 295/13 (2006.01) C07D 303/12 (2006.01) C07D 303/36 (2006.01) C07D 401/04 (2006.01)

Patent

CA 2102042

BENZ[e]INDENE DERIVATIVES A b s t r a c t The invention relates to novel, pharmaceutically active benz[e]indene derivatives, a process for the preparation thereof, pharmaceutical compositions comprising the same, further to the use of the said benz[e]indene derivatives in the treatment of certain diseases and in the preparation of pharmaceutical compositions suitable for the treatment of said diseases. The new benz[e]indene derivatives according to the invention correspond to the general formula Image (I), wherein A represents a group of the formula alk-NR1R2, wherein alk represents a C2-7 alkylene group optionally carrying a hydroxy substituent, R1 and R2 are independently hydrogen, C1-7 alkyl, C2-7 alkenyl, C2-7 alkynyl or C3-7 cycloalkyl; or R1 and R2 together with the nitrogen atom to which they are attached form a 4 to 7 membered ring, option- ally comprising an oxygen atom or a further nitro- gen atom, which latter may carry a phenyl, benzyl, pyridyl, pyrimidinyl or C1-3 alkyl substituent which substituents may, in turn, bear a hydroxy or methoxy group or a halogen atom; or R1 and R2 together with the nitrogen atom to which they are attached form a phthalimido group; or A represents pyrimidino, 2,3-epoxypropyl or a group of the formula -C(O)NHR, wherein R3 stands for C1-7 alkyl, C2-7 alkenyl or C3-8 cyclo- alkyl; and R denotes hydrogen or C1-7 alkyl, stereoisomers and optionally active isomers and the possible mixtures thereof, further acid addition salts and quaternary ammonium derivatives of these compounds.

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