Small molecule inhibition of rna/ligand binding

Details Small molecule inhibition of rna/ligand binding Small molecule inhibition of rna/ligand binding

C - Chemistry, Metallurgy

07

D

C07D 307/54 (2006.01) A61K 31/34 (2006.01) A61K 31/38 (2006.01) A61K 31/395 (2006.01) C07C 49/76 (2006.01) C07C 69/76 (2006.01) C07C 205/45 (2006.01) C07C 253/34 (2006.01) C07C 255/56 (2006.01) C07C 255/61 (2006.01) C07D 333/24 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2221867

Disclosed is a method for the inhibition of binding of a ligand to an RNA, the inhibition being mediated by a small organic molecule that binds to the RNA, thereby inhibiting ligand binding. A preferred class of small organic molecules are compounds exemplified by 2,5-Bis[3-(2-N,N-dimethylaminopropylamidino)phenyl]furan.

La présente invention concerne un procédé permettant d'inhiber la fixation d'un ligand sur un ARN, cette inhibition étant produite par une petite molécule organique qui se fixe à l'ARN, inhibant ainsi la fixation du ligand. Les petites molécules organiques appartiennent de préférence à la classe des composés dont l'exemple est le 2,5-bis[3-(2-N,N-diméthylaminopropylamidino)phényl]furanne.

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