Alkynyl pyrrolopyrimidines and related analogs as...

C - Chemistry – Metallurgy – 07 – D

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C07D 413/02 (2006.01) A61K 31/497 (2006.01) A61K 31/519 (2006.01) A61K 31/5355 (2006.01) A61K 31/661 (2006.01) C07D 487/04 (2006.01) C07F 9/09 (2006.01)

Patent

CA 2602257

Alkynyl pyrrolo[2,3-d]pyrimidines and related analogs are described and demonstrated to have utility as Heat Shock Protein 90 (HSP90) inhibiting agents used in the treatment and prevention of various HSP90 mediated disorders. Methods of synthesis and use of such compounds are also described and claimed.

L'invention concerne des alkynyles pyrrolo[2,3-d]pyrimidines et leurs analogues associés qui ont démontré leur utilité en tant qu'agents inhibiteurs de la protéine de choc thermique 90 (HSP90) et trouvant leur application dans le traitement et la prévention de différents troubles dans lesquels HSP90 joue un rôle. Elle concerne également des méthodes de synthèse et d'utilisation de ces composés.

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