C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) A61K 38/04 (2006.01) A61K 38/16 (2006.01) A61P 29/00 (2006.01) C07K 14/00 (2006.01) C07K 14/435 (2006.01)
Patent
CA 2658949
The present invention includes methods of inhibiting or suppressing cellular secretory processes. More specifically the present invention relates to inhibiting or reducing the release of inflammatory mediators from inflammatory cells by inhibiting the mechanism associated with the release of inflammatory mediators from granules in inflammatory cells. In this regard, the present invention discloses an intracellular signaling mechanism that illustrates several novel intracellular targets for pharmacological intervention in disorders involving secretion of inflammatory mediators from vesicles in inflammatory cells. Peptide fragments and variants thereof of MANS peptide as disclosed in the present invention are useful in such methods.
La présente invention concerne des procédés d'inhibition ou de suppression de procédés de sécrétion cellulaire. La présente invention concerne plus précisément l'inhibition ou la réduction de la libération de médiateurs inflammatoires de cellules inflammatoires par inhibition du mécanisme associé avec la libération de médiateurs inflammatoires de granules dans des cellules inflammatoires. La présente invention concerne ainsi un mécanisme de signalisation intracellulaire qui illustre plusieurs nouvelles cibles intracellulaires pour l'intervention pharmacologique dans des troubles impliquant la sécrétion de médiateurs inflammatoires de vésicules dans des cellules inflammatoires. Des fragments de peptides et leurs variantes de peptide MANS tels que décrits dans la présente invention sont utiles dans de tels procédés.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Biomarck Phamaceuticals Ltd.
LandOfFree
Inhibition of marcks-mediated degranulation by marcks... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Inhibition of marcks-mediated degranulation by marcks..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibition of marcks-mediated degranulation by marcks... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1534293