C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/445 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2310541
The invention concerns an isolated polypeptide constitutive of splice variants for human serotonin receptor whereof the amino acid sequence is selected among the sequence SEQ ID N· 2 of the 5-HT¿4(c)? polypeptide variant or the sequence SEQ ID N· 4 of the 5-HT¿4(d)? polypeptide variant, or any polypeptide fragment or biologically active derivative thereof. The invention also concerns the inverse agonist effect of ML 10375 on 5-HT4(c) and 5-HT4(d) receptors.
Cette invention concerne un polypeptide isolé constitutif de variants d'épissage du récepteur humain sérotoninergique dont la séquence d'acides aminés est choisie parmi la séquence SEQ ID N~ 2 du polypeptide variant 5- HT4(c), ou la séquence SEQ ID N~ 4 du polypeptide variant 5-HT4(d), ou tout fragment polypeptidique ou dérivé biologiquement actif de celui-ci. Cette invention concerne également l'effet agoniste inverse du ML 10375 sur les récepteurs 5-HT4(c) et 5-HT4(d)
Blondel Olivier
Dahmoune Yamina
Fischmeister Rodolphe
Gastineau Monique
Hoebeke Johan
Institut National de La Sante Et de La Recherche Medicale (inser
Robic
LandOfFree
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