Pyrone derivatives as protease inhibitors and antiviral agents

Details Pyrone derivatives as protease inhibitors and antiviral agents Pyrone derivatives as protease inhibitors and antiviral agents

C - Chemistry, Metallurgy

07

D

C07D 309/38 (2006.01) A61K 31/33 (2006.01) A61K 31/695 (2006.01) C07C 321/26 (2006.01) C07C 323/18 (2006.01) C07C 323/52 (2006.01) C07D 317/62 (2006.01) C07D 335/02 (2006.01) C07D 405/02 (2006.01) C07D 405/06 (2006.01) C07D 405/10 (2006.01) C07D 405/12 (2006.01) C07D 407/02 (2006.01) C07D 407/04 (2006.01) C07D 407/12 (2006.01) C07D 409/04 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2174124

The present invention relates to novel tri- and tetrasubstituted pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The pyrone derivatives are useful in the development of therapies for the treatment of baterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized pyrones and of related structures.

La présente invention se rapporte à des nouvelles pyrones trisubstituées et tétrasubstituées ainsi qu'à des structures apparentées, qui inhibent puissamment l'aspartyle protéase du VIH en bloquant le pouvoir infectant du VIH. Ces dérivés de la pyrone sont utiles dans le développement des thérapies destinées au traitement des infections et maldies bactériennes et virales, notamment le SIDA. La présente invention se rapporte également à des procédés de synthèse de pyrones multifonctionnalisées et de structures apparentées.

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