Pharmaceutical composition comprising anti-grp78 antibody as...

A - Human Necessities – 61 – K

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A61K 39/395 (2006.01) A61K 49/00 (2006.01) A61P 9/14 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C07K 16/18 (2006.01) C12N 15/09 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2679266

Disclosed is a novel pharmaceutical composition comprising an anti-GRP78 antibody. Specifically disclosed are: a novel method for treatment of cancer using an anti-GRP78 antibody; a novel cell growth inhibitor or anti-cancer agent comprising an anti-GRP78 antibody; and a novel anti-GRP78 antibody. It is tried to produce an anti-tumor antibody targeting for GRP78 which localizes on a cell membrane in a cancer cell, and an anti-GRP78 antibody can be successfully produced which can bind specifically to the cell surface of a cancer cell.

L'invention concerne une nouvelle composition pharmaceutique comportant un anticorps anti-GRP 78. L'invention concerne particulièrement : un nouveau procédé pour traiter le cancer en utilisant un anticorps anti-GRP 78 ; un nouvel inhibiteur de croissance cellulaire ou agent anticancéreux comportant un anticorps anti-GRP 78 ; et un nouvel anticorps anti-GRP 78. La production d'un anticorps antitumoral ciblant le GRP 78 qui se trouve sur une membrane cellulaire dans une cellule cancéreuse est tentée, et un anticorps anti-GRP 78, qui peut se lier spécifiquement à la surface de cellule d'une cellule cancéreuse, peut être produit avec succès.

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