Novel adenosine a3 receptor agonists

Details Novel adenosine a3 receptor agonists Novel adenosine a3 receptor agonists

C - Chemistry, Metallurgy

07

H

C07H 19/167 (2006.01) A61K 31/7076 (2006.01) A61P 9/02 (2006.01) A61P 9/10 (2006.01) A61P 25/04 (2006.01) A61P 25/08 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2537094

The invention realizes that a series of sulfonamido derivatives with a conserved uronamide group at the 5~ position provide superior A3 receptor affinity as well as selectivity. These new adenosine agonists are sulfonamido deritatives N-substituted with aliphatic groups (cyclic or linear) or aromatic radicals.

L'invention a permis de remarquer qu'une série de dérivés de sulfonamido ayant un groupe d'uronamide conservé à la position 5' fournit une affinité du récepteur A3 supérieure ainsi qu'une meilleure sélectivité. Ces nouveaux agonistes de l'adénosine sont des dérivés sulfonamido N-substitués avec des groupes aliphatiques (cycliques ou linéaires) ou des radicaux aromatiques.

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