Phosphonated arylethanolamine compounds with...

Details Phosphonated arylethanolamine compounds with... Phosphonated arylethanolamine compounds with...

C - Chemistry, Metallurgy

07

F

C07F 9/38 (2006.01) A61K 31/66 (2006.01) C07F 9/40 (2006.01) C07F 9/547 (2006.01) C07F 9/655 (2006.01)

Patent

CA 2140916

A compound of formula (I) or a pharmaceutically acceptable salt, ester or amide thereof, or a pharmaceutically acceptable solvate thereof,wherein R0 represents a substituted or unsubstituted aryl group; R1 represents hydrogen or an alkyl group; R2 represents a moiety of formula (a) wherein R4 and R5 each independently represent hydrogen, alkyl, hydroxyalkyl, cyc- loalkyl or R4 together with R5 represents (CH2)n wherein n is 2, 3 or 4; T represent hydrogen, nitrile or a group -CO.R5 wherein R5 represents hydroxy, alkoxy or a group -NRtRu wherein Rt and Ru independently represent hydrogen, alkyl or Rt and Ru together with the nitrogen to which they are attached represent a saturated heterocyclic group; and R3 represents hy- drogen, halogen, alkyl or alkoxy; a process for the preparation of such a compound, a pharmaceutical composition com- prising such a compound and the use of such a compound in medicine.

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