Immunogenic compositions and methods of use

Details Immunogenic compositions and methods of use Immunogenic compositions and methods of use

C - Chemistry, Metallurgy

07

K

C07K 17/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2627376

Disclosed herein are immunogenic compositions comprising a multilayer film comprising two or more layers of polyelectrolytes, wherein adjacent layers comprise oppositely charged polyelectrolytes. A first layer polyelectrolyte comprises an antigenic polypeptide comprising one or more surface adsorption regions covalently linked to one or more antigenic determinant regions, wherein the antigenic polypeptide and the one or more surface adsorption regions have the same polarity. The immunogenic compositions may be employed in methods of eliciting an immune response in a vertebrate organism.

La présente invention concerne des compositions immunogènes comprenant un film multicouche qui comprend au moins deux couches de polyélectrolytes, des couches adjacentes comprenant des polyélectrolytes de charge opposée. Une première couche de polyélectrolyte comprend un polypeptide antigénique qui comprend une ou plusieurs zones d'adsorption de surface liées de façon covalente à une ou plusieurs zones de déterminant antigénique, le polypeptide antigénique et la zone ou les zones d'adsorption de surface ayant la même polarité. Les compositions immunogènes peuvent être employées dans le cadre de procédés pour obtenir une réponse immunitaire chez un organisme vertébré.

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