Direct targeting binding proteins

Details Direct targeting binding proteins Direct targeting binding proteins

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 45/06 (2006.01) A61K 47/48 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C12N 5/12 (2006.01) C12N 15/63 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2463672

The present invention relates to multivalent, monospecific binding proteins. These binding proteins comprise two or more binding sites, where each binding site specifically binds to the same type of target cell, and preferably with the same antigen on such a target cell. The present invention further relates to compositions of monospecific diabodies, triabodies, and tetrabodies, and to recombinant vectors useful for the expression of these functional binding proteins in a microbial host. Also provided are methods of using invention compositions in the treatment and/or diagnosis of tumors.

L'invention concerne des protéines de liaison multivalentes monospécifiques. Ces protéines de liaison comprennent au moins deux sites de liaison, chaque site de liaison se liant spécifiquement au même type de cellule cible, et de préférence avec le même antigène sur cette cellule cible. L'invention concerne également des compositions de dianticorps, trianticorps et tétraanticorps monospécifiques, ainsi que des vecteurs recombinants utiles à l'expression de ces protéines de liaison fonctionnelles dans un hôte microbien. L'invention concerne enfin des procédés d'utilisation de ces compositions dans le traitement et/ou le diagnostic de tumeurs.

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