C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/16 (2006.01) C12N 5/07 (2010.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 1/02 (2006.01) C12Q 1/02 (2006.01) C12Q 1/18 (2006.01) C12Q 1/24 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2590583
Monoclonal antibodies and other proteins that specifically bind to cells positive for endosialin are provided. The antibodies and proteins are useful in the isolation of endosialin-positive cells, particularly cells associated with neovascularization associated with cancer and neovascular disease. The invention is also related to cells that are isolated using monoclonal antibodies; antibody derivatives, such as chimeric and humanized monoclonal antibodies; antibody fragments; mammalian cells expressing the monoclonal antibodies, derivatives and fragment; and methods of detecting and isolation endosialin-positive cells using the antibodies, derivatives and fragments.
L'invention concerne des anticorps monoclonaux et d'autres protéines monoclonales qui se lient de manière spécifique à des cellules positives pour l'endosialine. Ces anticorps et protéines sont utiles pour isoler des cellules positives pour l'endosialine, en particulier des cellules associées à la néovascularisation associée au cancer et aux maladies néovasculaires. L'invention concerne également des cellules qui sont isolées au moyen d'anticorps monoclonaux ; des dérivés d'anticorps, de type anticorps monoclonaux chimères et humanisés ; des fragments d'anticorps ; des cellules de mammifères exprimant les anticorps monoclonaux, dérivés et fragments ; et des procédés de détection et d'isolation de cellules positives pour l'endosialine au moyen desdits anticorps, dérivés et fragments.
Deshmukh Gaurav
Grasso Luigi
Nicolaides Nicholas
Sass Philip
Gowling Lafleur Henderson Llp
Morphotek Inc.
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