Elongase genes and uses thereof

Details Elongase genes and uses thereof Elongase genes and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) A01H 5/00 (2006.01) A01K 67/027 (2006.01) A23K 1/00 (2006.01) A23L 1/29 (2006.01) A61K 8/92 (2006.01) A61K 31/215 (2006.01) A61Q 19/00 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 5/10 (2006.01) C12N 9/00 (2006.01) C12N 9/10 (2006.01) C12N 15/09 (2006.01) C12N 15/63 (2006.01) C12P 7/64 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2417484

The subject invention relates to the identification of several genes involved in the elongation of polyunsaturated acids (i.e., "elongases") and to uses thereof. At least two of these genes are also involved in the elongation of monounsaturated fatty acids. In particular, elongase is utilized in the conversion of gamma linolenic acid (GLA) to dihomogamma linolenic acid (DGLA) and in the conversion of DGLA or 20:4n-3 to eicosapentaenoic acid (EPA). DGLA may be utilized in the production of polyunsaturated fatty acids, such as arachidonic acid (AA), docosahexaenoic acid (DHA), EPA, adrenic acid, w6- docosapentaenoic acid or w3-docosapentaenoic acid which may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.

La présente invention concerne l'identification de plusieurs gènes impliqués dans l'allongement d'acides polyinsaturés (c'est-à-dire, "élongases") ainsi que leurs utilisations. Au moins deux de ces gènes sont également impliqués dans l'allongement d'acides gras monoinsaturés. En particulier, l'élongase est utilisée dans la conversion d'acide linolénique gamma (GLA) en acide linolénique dihomogamma (DGLA), et dans la conversion de DGLA ou 20:4n-3 en acide eicosapentanoïque (EPA). Le DGLA peut être utilisé dans la production d'acides gras polyinsaturés, tels que l'acide arachidonique (AA), l'acide docosahexanoïque (DHA), EPA, l'acide adrénique, l'acide .omega.6-docosapentanoïque ou l'acide .omega.3-docosapentanoïque pouvant être ajoutés à des compositions pharmaceutiques, des compositions nutritionnelles, des aliments pour animaux de même que d'autres produits tels que des cosmétiques.

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