C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/211, 260/255
C07D 403/10 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) C07D 239/36 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01) C07F 9/645 (2006.01)
Patent
CA 2033121
4-17893/+ Diaza compounds Abstract Diaza compounds of the formula Image (1), in which one of the radicals R1 and R2 is an aliphatic hydrocarbon radical which is unsubstituted or substituted by halogen or hydroxyl or a cycloaliphadc or araliphadc hydrocarbon radical and the other of the radicals R1 and R2 is the group of the formula Image (Ia), in which Z1 is alkylene, O, S(O)m or N(R), R5 is carboxyl, haloalkanesulfonylamino, SO3H,PO2H2, PO3H2 or 5-tetrazolyl and the rings A and B independently of one another are unsubsdtuted or substituted by an aliphatic hydrocarban radical which, if desired, is interrupted by O and is unsubstituted or substituted by hydraxyl or halogen, hydroxyl which, if desired, is etherified by an aliphatic alcohol, halogen, carboxyl which, if desired, is esterified or amidated, or 5-tetrazolyl, and either R3 is halogen, acyl, an aromatic hydrocarbon radical, carboxyl which, if desired, is esterified or amidated, cyano, SO3H, PO2H2, PO3H2, 5-tetrazolyl, substituted or unsubsdtuted sulfamoyl or acylamino or is -Z2-R', wherein Z2 is a bond or is O, S(O)m or N(R) and R' is hydrogen or an aliphatic hydrocarbon radical which, if desired, is interrupted by O or S(O)m and is unsubstituted or substituted by halogen, hydroxyl, substituted or unsubstituted amino or carboxyl which, if desired, is esterified or amidated, and R4 is an aliphatic hydrocarbon radical which, if desired, is interrupted by O or S(O)m and is unsubstituted or substituted by carboxyl which, if desired, is esterified or amidated, hydroxyl which, if desired, is etherified by an aromatic alcohol, substituted or unsubstituted amino, S(O)m-R or an aromatic hydrocarbon radical, or R3 and R4 together represent alkylene, R in each case being hydrogen or an aliphatic hydrocarbon radical and m in each case being 0, 1 or 2, in free form or in salt form, can be used as pharmaceutical active ingredients and can be prepared in a manner known per se.
Buhlmayer Peter
Herold Peter
Ag Ciba-Geigy
Fetherstonhaugh & Co.
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