Generation of neural stem cells from undifferentiated human...

C - Chemistry – Metallurgy – 12 – N

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C12N 5/0797 (2010.01) C12N 5/0735 (2010.01) C12N 5/079 (2010.01) A61K 35/30 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2488429

The present invention relates to the generation of neural cells from undifferentiated human embryonic stem cells. In particular it relates to directing the differentiation of human ES cells into neural progenitors and neural cells and the production of functioning neural cells and/or neural cells of a specific type. The invention also includes the use of these cells for the treatment of neurological conditions such as Parkinson's disease.

La présente invention se rapporte à la génération de cellules neurales provenant de cellules souches embryonnaires humaines non différenciées. L'invention se rapporte plus particulièrement à l'orientation de la différenciation de cellules ES humaines en progéniteurs neuraux et cellules neurales ainsi que la production de cellules neurales de fonctionnement et/ou de cellules neurales d'un type spécifique. L'invention se rapporte en outre à l'utilisation de ces cellules pour le traitement de pathologies neurologiques, notamment la maladie de Parkinson.

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