Protease inhibitors of the coagulation cascade isolated from...

Details Protease inhibitors of the coagulation cascade isolated from... Protease inhibitors of the coagulation cascade isolated from...

C - Chemistry, Metallurgy

07

D

C07D 209/02 (2006.01) A61K 31/40 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2470811

The present invention is directed toward a composition comprising a compound isolated from Dysidea species sponges that is capable of inhibiting serine proteases of the coagulation cascade. In particular, this composition inhibits the TF/VIIa complex of the coagulation cascade. The invention is also directed toward methods employing this composition as a part of anticoagulant therapy.

La présente invention concerne une composition renfermant un composé isolé à partir de l'espèce Dysidea, qui est capable d'inhiber les sérine protéases de la cascade de coagulation. En particulier, la composition de l'invention inhibe le complexe TF/VIIa de la cascade de coagulation. L'invention se rapporte également à des procédés dans lesquels il est fait appel à cette composition dans le cadre d'une thérapie anticoagulante.

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