Cyano containing oxamic acids and derivatives as thyroid...

Details Cyano containing oxamic acids and derivatives as thyroid... Cyano containing oxamic acids and derivatives as thyroid...

C - Chemistry, Metallurgy

07

C

C07C 255/60 (2006.01) A61K 31/275 (2006.01) A61K 31/277 (2006.01) A61K 31/33 (2006.01) A61K 45/06 (2006.01) A61P 3/00 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) A61P 5/00 (2006.01) A61P 5/14 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 19/10 (2006.01) A61P 25/24 (2006.01) C07C 317/40 (2006.01) C07C 323/41 (2006.01)

Patent

CA 2299760

The present invention provides novel compounds of the Formula (See formula I) and prodrugs thereof, geometric and optical isomers thereof, and pharmaceutically acceptable salts of such compounds, prodrugs and isomers, wherein R4 - R8 and X are as described herein. Pharmaceutical compositions containing such compounds, prodrugs, isomers or pharmaceutically acceptable salts thereof, and methods, pharmaceutical compositions and kits for treating obesity, hyperlipidemia, thyroid disease, hypothyroidism and related disorders and diseases such as diabetes mellitus, atherosclerosis, hypertension, coronary heart disease, hypercholesteremia, depression and osteoporosis are also provided.

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