Use of polypeptides of the cupredoxin family in cancer therapy

A - Human Necessities – 61 – K

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A61K 38/16 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2535581

Cytotoxic factors having use in modulating cell death, and their use in methods of treating necrosis or apoptosis-~related conditions are disclosed. The invention also relates to methods for identifying active agents useful in treating conditions related to cell death or uncontrolled growth. The present inventors have found that different microorganisms produce different cylotoxic factor(s) having anticancer activity. The substantially pure cytotoxic factors can be used in a method of treating an infectious disease or a cancer.

L'invention concerne des facteurs cytotoxiques utilisés dans la modulation de la mort cellulaire ainsi que leur utilisation dans des méthodes de traitement de pathologies associées à la nécrose ou à l'apoptose. Cette invention concerne également des méthodes d'identification d'agents actifs utiles dans le traitement de pathologies associées à la mort cellulaire ou à la croissance cellulaire anarchique. Les présents inventeurs ont découvert que différents microorganismes produisent différents facteurs cytotoxiques à activité anticancéreuse. Des facteurs cytotoxiques sensiblement purs peuvent être utilisés dans une méthode de traitement d'une maladie infectieuse ou d'un cancer.

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