Use of .delta.5-androstene-3.beta.-ol-7,17-dione in the...

Details Use of .delta.5-androstene-3.beta.-ol-7,17-dione in the... Use of .delta.5-androstene-3.beta.-ol-7,17-dione in the...

A - Human Necessities

61

K

A61K 31/56 (2006.01) A61K 31/565 (2006.01) A61K 31/566 (2006.01) A61P 19/02 (2006.01)

Patent

CA 2311471

Arthritis can be treated by administering therapeutic amounts of .DELTA.5- androstene-3.beta.-ol-7,17-dione and metabolizable precursors thereof, such as .DELTA.5-androstene-3.beta.-acetoxy-7,17-dione, which are readily metabolized in vivo to .DELTA.5-androstene-3.beta.-ol-7,17-dione but are not appreciably metabolizable in vivo to androgens, estrogens or dehydroepiandrosterone. Such treatment can be prophylactic, ameliorative or curative in nature.

Il est possible de traiter l'arthrite en administrant des quantités thérapeutiques de .DELTA.5-androstène-3.beta.-ol-7,17-dione et ses précurseurs métabolisables, du type .DELTA.5-androstène-3.beta.-acétoxy-7,17-dione, facilement métabolisables in vivo en .DELTA.5-androstène-3.beta.-ol-7,17-dione, mais non métabolisables in vivo, de manière appréciable, en androgènes, estrogènes ou déhydroépiandrostérone. Le traitement considéré peut avoir la triple finalité suivante : prophylaxie, amélioration ou action thérapeutique.

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