C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 19/067 (2006.01) C07H 19/167 (2006.01)
Patent
CA 2577339
The purpose of the present invention is to develop a system for efficiently constituting cyanoethyl ethers under mild conditions and probability of the ethers as functional groups for imparting specific functions and to make a contribution to the production of novel functional nucleic acids. The present invention relates to a nucleoside that is represented by the general formula (I) or a nucleotide derived therefrom: [Chemical formula 1] (see formula I) wherein X and Y may be the same as or different from each other, and are hydrogen, optionally substituted silyl group, 4-methoxytrityl group, 4,4'-dimethoxytrityl group or a group represented by the general formula (II): [Chemical formula 2] (see formula II) wherein R1 and R2 may be the same as or different from each other, representing an alkyl group having 1-7 carbon atoms such as diisopropyl, or they are united with each other to form a ring structure, R3 represents a protective group for a phosphoric acid such as 2-cyanoethyl; and B1 represents an optionally substituted pyrimidine or purine base.
L'invention vise à développer un système pour fabriquer efficacement des éthers de cyanoéthyle dans des conditions douces et avec la possibilité que les éthers soient des groupes fonctionnels pour conférer des fonctions spécifiques et donc contribuer à la création de nouveaux acides nucléiques fonctionnels. L'invention concerne les nucléosides représentés par la formule générale (I) et les nucléotides qui en sont dérivés : (I) où X et Y représentent chacun indépendamment un hydrogène, facultativement un silyle substitué, du 4-méthoxytrityle, du 4,4'-diméthoxytrityle ou un groupe représenté par la formule générale (II) : (II) (où R1 et R2 représentent chacun indépendamment un alkyle ayant de 1 à 7 atomes de carbones ou R1 et R2 sont unis pour former une structure cyclique, et R3 est un groupe de protection pour l'acide phosphorique) et B1 est une pyrimidine facultativement substituée ou une base purine.
Saneyoshi Hisao
Seio Kohji
Sekine Mitsuo
Japan Science And Technology Agency
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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