Compositions and methods for cell killing

Details Compositions and methods for cell killing Compositions and methods for cell killing

A - Human Necessities

61

K

A61K 31/74 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) C12N 1/00 (2006.01) C12Q 1/04 (2006.01)

Patent

CA 2628271

A method of generating a change in a cellular process of a target cell is disclosed. The method comprises contacting the target cell with a solid buffer, so as to alter an intracellular pH value in at least a portion of the cell, thereby generating the change in a cellular process of a target cell of a multicellular organism. The method may be used to kill either eukaryotic or prokaryotic cells. Pharmaceutical compositions and devices are also enclosed.

Cette invention concerne une méthode propre à générer un changement dans le processus cellulaire d'une cellule cible. Cette méthode consiste à mettre une cellule cible en contact avec un tampon solide afin de modifier la valeur du pH intracellulaire dans au moins une partie de la cellule et, partant, de générer un changement dans le processus cellulaire d'une cellule cible d'organisme multicellulaire. Cette méthode peut s'utiliser pour détruire des cellules soit eukaryotiques, soit prokaryotiques. Sont également décrits des compositions pharmaceutiques et des dispositifs.

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