Non-transgenic animal model of alzheimer's disease

Details Non-transgenic animal model of alzheimer's disease Non-transgenic animal model of alzheimer's disease

A - Human Necessities

01

K

A01K 67/00 (2006.01) A01K 49/00 (2006.01) A01K 67/027 (2006.01) A61K 49/00 (2006.01) C07K 14/47 (2006.01) C12N 15/00 (2006.01) C12N 15/10 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2307196

The invention features a method of inducing amyloid plaque deposition in a mammal by infusing into the brain of the mammal an amyloid peptide at a basic pH, a nontransgenic animal model for Alzheimer's disease, and methods of identifying compounds to treat Alzheimer's disease.

La présente invention concerne un procédé permettant d'induire un dépôt de plaques amyloïdes chez un mammifère en injectant dans le cerveau du mammifère un peptide amyloïde avec un pH de base, et elle concerne également un modèle animal non transgénique de la maladie d'Alzheimer ainsi que des procédés permettant d'identifier des composés destinés au traitement de la maladie d'Alzheimer.

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