A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) C07G 99/00 (2009.01) A61K 31/00 (2006.01) A61K 39/395 (2006.01) A61P 9/00 (2006.01) A61P 27/02 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2378179
Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy.
L'invention concerne des compositions et des méthodes destinées à stimuler ou inhiber l'angiogenèse et/ou la cardiovascularisation chez les mammifères, et notamment chez l'homme. Des compositions pharmaceutiques contiennent des polypeptides, ou leurs antagonistes, identifiés pour une ou plusieurs de ces utilisations. Parmi les troubles pouvant être diagnostiqués, évités ou traités avec ces compositions, on compte certains traumatismes, par exemple les blessures, et différents cancers et troubles des vaisseaux, tels que l'artériosclérose et l'hypertrophie cardiaque.
Gerritsen Mary E.
Williams P. Mickey
Genentech Inc.
Smart & Biggar
LandOfFree
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