2-heteroaryl-pyrazolo-[4, 3-e]-1, 2,...

Details 2-heteroaryl-pyrazolo-[4, 3-e]-1, 2,... 2-heteroaryl-pyrazolo-[4, 3-e]-1, 2,...

C - Chemistry, Metallurgy

07

D

C07D 487/14 (2006.01) A61K 31/519 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2622741

Compounds having the structural formula (I) or a pharmaceutically acceptable salt thereof, wherein R is R1-isoxazolyl, R1-oxadiazolyl, R1-dihydrofuranyl, R1-pyrazolyl, R1-imidazolyl, R1-pyrazinyl or R1-pyrimidinyl; R1 is 1 , 2 or 3 substituents selected from H, alkyl, alkoxy and halo; Z is optionally substituted-aryl, or optionally substituted-heteroaryl; are disclosed, as well as their use in the treatment of central nervous system diseases, in particular Parkinson's disease and Extra Pyramidal Syndrome, pharmaceutical compositions comprising them, and combinations with other agents.

Composés représentés par la formule (I) ou un de leurs sels acceptables sur le plan pharmaceutique, dans laquelle R représente R1-isoxazolyle, R1-oxadiazolyle, R1-dihydrofuranyle, R1-pyrazolyle, R1-imidazolyle, R1-pyrazinyle ou R1-pyrimidinyle; R1 représente 1, 2 ou 3 substituants sélectionnés dans H, alkyle, alcoxy et halo; Z représente aryle éventuellement substitué ou hétéroaryle éventuellement substitué. L'invention concerne également l'utilisation de ces composés pour traiter des maladies du système nerveux central, en particulier, la maladie de Parkinson et la syndrome extra pyramidal, des compositions pharmaceutiques les contenant et leurs combinaisons avec d'autres agents.

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