Methods for treating substance-related disorders

Details Methods for treating substance-related disorders Methods for treating substance-related disorders

A - Human Necessities

61

K

A61K 31/325 (2006.01)

Patent

CA 2616721

This invention is directed to a method for preventing, treating or ameliorating substance-related disorders, in a subject in need thereof comprising administering to the subject an effective amount of a compound selected from: Formula (I), or Formula (II) or pharmaceutically acceptable forms thereof, wherein phenyl is substituted at X with one to five halogen atoms selected from the group consisting of fluorine, chlorine, bromine and iodine; and, R1, R2, R3, R4, R5 and R6 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; wherein C1-C4 alkyl is optionally substituted with phenyl (and, wherein phenyl is optionally substituted with substituents independently selected from the group consisting of halogen, C1-C4 alkyl, C1 C4 alkoxy, amino, nitro and cyano). In addition, methods are included involving co-administration of compounds of the invention with one or more compounds known to treat substance-induced disorders.

Cette invention se rapporte à un procédé destiné à prévenir, traiter ou réduire des troubles liés à des substances, chez un sujet en ayant besoin, comprenant l~administration à un patient d~une dose efficace d~un composé sélectionné à partir de : la Formule (I), la Formule (II) ou des formes acceptables sur le plan pharmacologique de ces dernières, dans lesquelles le phényle est substitué à X par un à cinq atomes d~halogène sélectionnés dans un groupe consistant à du fluorine, du chlore, du brome et de l~iode ; et R1, R2, R3, R4, R5 et R6 sont indépendamment sélectionnés à partir d~un groupe consistant en de l~hydrogène et un alkyl C1-C4 ; dans lesquelles l~alkyl C1-C4 est subsidiairement substitué par le phényle (et dans lesquelles le phényle est subsidiairement substitué par des substituants indépendamment sélectionnés dans un groupe consistant en halogène, en alkyl C1-C4, en alkoxy C1 C4, amino, nitro et cyano). En outre, l~invention se rapporte à des procédés impliquant la co-administration de composants de l~invention avec un ou plusieurs composants connus pour traiter des troubles liés à des substances.

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