Cyclic-dinucleotides and its conjugates as adjuvants and...

A - Human Necessities – 61 – K

Patent

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A61K 39/00 (2006.01) A61K 31/00 (2006.01) A61K 31/47 (2006.01) A61K 31/70 (2006.01) A61K 31/7084 (2006.01) A61K 39/39 (2006.01) A61P 15/00 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2624903

The present invention relates to new adjuvants and the uses in pharmaceutical compositions, like in vaccines. In particular, the present invention provides new compounds useful as adjuvants and/or immunomodulators for prophylactic and/or therapeutic vaccination in the treatment of infectious diseases, inflammatory diseases, autoimmune diseases, tumours, allergies as well as for the control of fertility in human or animal populations. The compounds are particularly useful not only as systemic, but preferably as mucosal adjuvants. In addition, the invention relates to its uses as active ingredients in pharmaceutical compositions.

La présente invention concerne de nouveaux adjuvants et leurs utilisations dans des compositions pharmaceutiques, tels que dans des vaccins. En particulier, la présente invention concerne de nouveaux composés utiles en tant qu'adjuvants et/ou immunomodulateurs pour la vaccination prophylactique et/ou thérapeutique dans le traitement de maladies infectieuses, de maladies inflammatoires, de maladies auto-immunes, de tumeurs, d'allergies ainsi que pour le contrôle de la fertilité chez des populations humaines ou animales. Lesdits composés sont particulièrement utiles non seulement en tant qu'adjuvants systémiques, mais de préférence en tant qu'adjuvants mucosaux. En outre, l'invention concerne leurs utilisations en tant qu'ingrédients actifs dans des compositions pharmaceutiques.

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