Highly absorbable solid preparations containing sitafloxacin...

A - Human Necessities – 61 – K

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Details

A61K 31/4709 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61K 47/12 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2417764

A solid preparation improved in oral absorption and reduced in fluctuations of oral absorption can be obtained by incorporating an organic acid, particularly tartaric acid, in a solid preparation having, as an active ingredient, a high content of a quinolone compound, particularly sitafloxacin, having poor water solubility at pH around neutrality.

L'invention concerne une préparation solide contenant comme ingrédient actif un volume important de composé quinolone faiblement soluble dans l'eau à un pH proche du neutre, en particulier de la sitafloxacine. L'absorbabilité et la diffusion perorales de cette préparation peuvent être améliorées par adjonction d'un acide organique, notamment de l'acide tartrique.

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