Modified thrombopoietin with reduced immunogenicity

Details Modified thrombopoietin with reduced immunogenicity Modified thrombopoietin with reduced immunogenicity

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 38/04 (2006.01) C07K 14/52 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2439168

The present invention relates to polypeptides to be administered especially to humans and in particular for therapeutic use. The polypeptides are modified polypeptides whereby the modification results in a reduced propensity for the polypeptide to elicit an immune response upon administration to the human subject. The invention in particular relates to the modification of human thrombopoietin (TPO) to result in TPO proteins that are substantially non- immunogenic or less immunogenic than any non-modified counterpart when used in vivo.

L'invention concerne des polypeptides destin~s ~ Útre administr~s notamment ~ des Útres humains, et en particulier pour un usage th~rapeutique. Ces polypeptides sont modifi~s, la modification r~duisant la tendance du polypeptide ~ d~clencher une r~action immunitaire lorsqu'on l'administre ~ un sujet humain. L'invention concerne en particulier la modification de thrombopo~~tine humaine (TPO) en vue d'obtenir des prot~ines de TPO sensiblement non immunog­nes ou moins immunog­nes que toute autre prot~ine non modifi~e, utilis~e in vivo.

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