C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) C07K 14/71 (2006.01) C12N 5/06 (2006.01) C12N 15/85 (2006.01) C12Q 1/04 (2006.01) C12Q 1/48 (2006.01)
Patent
CA 2162677
The present invention provides an in vitro cell culture system, based on neuronal cells comprising oncogenic derivatives of the NGF-receptor gene NTRK1 and exhibiting NGF-independent neuronal differentiation closely resembling NGF-induced cellular responses in normal cells, but differing from these responses by displaying cellular degeneration after prolonged culture periods. The present invention furthermore provides eukaryotic expression vectors containing cDNAs coding for the NTRK1-derived oncoprotein TRK-T1, and a method to obtain said neuronal cells by transformation with eukaryotic expression vectors coding for oncogenic derivatives of NTRK1.
Greco Angela
Pierotti Marco A.
Istituto Nazionale Per Lo Studio E. La Cura Dei Tumori
Kirby Eades Gale Baker
LandOfFree
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