An improved process for the preparation of mycophenolate...

Details An improved process for the preparation of mycophenolate... An improved process for the preparation of mycophenolate...

C - Chemistry, Metallurgy

07

D

C07D 413/12 (2006.01)

Patent

CA 2533326

A process of manufacturing mycophenolate mofetil comprising reacting an alkyl ester of mycophenolic acid, with 2-(4-morpholinyl) ethanol in the presence of a catalyst selected from a form of zinc selected from metallic zinc or at least one zinc salt or at least one zinc oxide, or a form of calcium selected from metallic calcium or at least one calcium salt or at least one calcium oxide.

Divulgation d'un procédé de production de mycophénolate mofétil comprenant la réaction d'un ester alkylique d'acide mycophénolique avec du 2-(morpholin-4-yl)éthanol en présence d'un catalyseur choisi entre une forme de zinc, zinc métallique ou au moins un sel de zinc ou au moins un oxyde de zinc, ou une forme de calcium, calcium métallique ou au moins un sel de calcium ou au moins un oxyde de calcium.

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